Need Help?
Not a member yet? Join today and receive:
Daily Digest Emails, SDI Newsletters, Access to Post on our Forum, Submit your Survivor Story, and more!
Become a member today - It's free! | Read more about member benefits! | Already a member? Login now!

Interactive Health Communication for longer, better lives.

Reversal of multidrug resistance by curcumin in multiple myeloma

curcumin supplementation reverses multidrug resistance

Article Type: Therapies
Author: Zuo X Zhang K Xiao Q Xiao H Shrestha UK.
Publication Date: . 2009 Sep 15
Source: 1: Ann Hematol.
Source Type: online publication

In conclusion, curcumin reversed multidrug resistance of MOLP-2/R through inhibition of FA/BRCA pathway.

 

Most patients with multiple myeloma (MM) will relapse eventually due to the acquired multidrug resistance (MDR). The objective of this study was to explore the reversal effect of curcumin on the MDR of human MM cell line, MOLP-2/R, and analyze the role of Fanconi anemia (FA)/BRCA pathway in this process. MOLP-2/R was selected by stepwise exposure of parental MOLP-2 cells to increasing concentrations of melphalan. The MTT assay was used to detect the reversal ratio of curcumin. The FANCD2 monoubiquitination expression was detected by western blotting to explore the role of FA/BRCA pathway. Cell cycle, apoptosis, and intracellular drug concentration were analyzed by flow cytometry. The results indicated that combination of melphalan with curcumin had stronger effects on the proliferation inhibition, inducement of apoptosis, G2/M phase arrest, and enhancement of intracellular drug concentration than melphalan alone in MOLP-2/R cells. These effects were accompanied with inhibition of FA/BRCA pathway by down regulation of FANCD2 protein monoubiquitination in a dose-dependent manner. In conclusion, curcumin reversed multidrug resistance of MOLP-2/R through inhibition of FA/BRCA pathway. The possible mechanisms include (1) reduction of DNA damage repair and stimulation of apoptosis of tumor cells through inhibition of FA/BRCA pathway, which is important for DNA repair, and (2) achievement of high concentration in target cells. Curcumin may be a safe reversal agent of multidrug resistance with low-dose DNA cross-linking agents.

do they work with valcade, ?

does liopic acid work for nerve damage in multiple myeloma

Anonymous-

I can't tell from your question exactly what you are asking.

Does ALA and curcumin "work with velcade" meaning does curcumin eliminate the body's resistance to velcade?  The article above does not specify which chemos so I would ask your onc this question.

As for the second question, does ALA work for nerve damage?  All I can say is that ALA is one the list of supplements common to lists from places like Dana-Farber to manage peripheral neuropathy so from this perspective, I would say that ALA works for nerve damage.

David Emerson

ALA worked EXCELLENT for us.  Dave took 800 mg 2 daily and up to 2400 mg daily if needed.  We were only asked not to take it during the 4 days of high dose chemotherapy when getting a consolidation or stem cell transplant.  We honored that, and took the neurontin if needed and then switched back to the ALA. You should include B6, B 12 shots if you can get them from your doctor, and folic acid.  PN in healthy people is caused by a Vitamin B deficiency.  Hope that helps.

Lori

"Live isn't about waiting for the storm to pass. It's learning how to dance the rain."

Our christian louboutin sale online store recommand christian louboutin pumps and christian louboutin boots. We are sure that our cheap christian louboutin shoes are hot sale on the market. The customers who bought the christian louboutin uk are satisfied with our service. To be a sexy and charming lady from wearring christian louboutin shoes.

Generally, many people like new things. The same is true for supra shoes. If you used wearing Supra Skytop Shoes, many people would like to exchange a pair of Supra Skateboarding Shoes to wear. But for a few people, they like supra shoes uk very loyal. They often buy shoe from supra shoes online, and they don't want to buy any others, even the shoes are Nike Free Shoes or Vibram Five Fingers Shoes.

puma shoes
| cheap puma shoes
| puma shoes store
Men's puma shoes
SF Drift Cat
| Puma - SF Drift Cat
| Puma - SF Drift Cat shoes
Baylee Future Cat II
| Puma Baylee Future Cat II
| Puma Baylee Future Cat II shoes
Doshu Combat
| Puma Doshu Combat
| Puma Doshu Combat Shoes
Ducati Testastretta
| Puma Ducati Testastretta
| Puma Ducati Testastretta shoes
Fluxion II
| Puma Fluxion II shoes
Cat GT Ferrari
| Future Cat GT Ferrari
| Puma Future Cat GT Ferrari
| Puma Future Cat GT Ferrari shoes
Cat Lo Engine
| Future Cat Lo Engine
| Puma Future Cat Lo Engine
| Puma Future Cat Lo Engine shoes
Cat Low
| Future Cat Low
| Puma Future Cat Low
| Puma Future Cat Low shoes
Kimi Raikkonen
| Puma Kimi Raikkonen
| Puma Kimi Raikkonen shoes
Lazy Insect
| Puma Lazy Insect
| Puma Lazy Insect shoes
running shoes
| Puma running shoes
Trionfo Low
| SF Trionfo Low
| Puma SF Trionfo
| Puma SF Trionfo Low shoes
Speed Cat
| Puma Speed Cat
| Puma Speed Cat shoes
Speed Cat Big
| Puma Speed Cat Big
| Puma Speed Cat Big shoes
Trionfo Lo L II
| Puma Trionfo Lo L II
| Puma Trionfo Lo L II shoes
Trionfo Low BAYLEE
| Puma Trionfo Low BAYLEE
| Puma Trionfo Low BAYLEE shoes
Women's puma shoes
Basket Brights
| Puma Basket Brights
| Puma Basket Brights shoes
Baylee Future Cat
|Puma Baylee Future Cat
| Puma Baylee Future Cat shoes
Drift Cat
| Puma Drift Cat
| Puma Drift Cat shoes
Cat Low
| Engine Cat Low
| Puma Engine Cat Low shoes
Patent FS
| Espera Patent
| Puma Espera Patent FS
| Puma Espera Patent FS shoes
Tessuto Shoes
| Ferro Tessuto shoes
| Puma Ferro Tessuto Shoes
Cat Lo
| Future Cat Lo
| Puma Future Cat Lo
| Puma Future Cat Lo shoes
Low BAYLEE
| Trionfo Low BAYLEE
| Puma Trionfo Low BAYLEE
| Puma Trionfo Low BAYLEE shoes
Repli Cat
| Puma Repli Cat
| Puma Repli Cat shoes
SF Drift Cat
| Puma SF Drift Cat
| Puma SF Drift Cat shoes
Speed Cat Big
| Puma Speed Cat
| Puma Speed Cat Big shoes
Speed Cat Suede
| Puma Speed Cat Suede
| Puma Speed Cat Suede shoes
puma shoes
| cheap puma shoes
| puma shoes store
puma shoes
| cheap puma shoes
| puma shoes store
puma shoes
| cheap puma shoes
| puma shoes store (...) Tiffany
| Tiffanys
| Tiffany Store
| Tiffany UK
| Tiffany & CO
| Tiffany Necklaces
| Tiffany Jewellery
| Tiffany Silver
| Jewelry Bracelets
| Jewelry Store
| Silver Jewelry
| Tiffany Accessories
| Tiffany Bangles
| Tiffany Bracelets
| Tiffany Earrings
| Tiffany Necklaces
| Tiffany Rings
| Tiffany Jewellery
| Tiffany Jewellery
| Tiffany Jewellery

DGreatugg boots, warm and comfy. They're really the wrong length (height) to wear with jeans but they work with most other pants.
cheap ugg bootsJeans tend to slip out of them but wool stays put. They are warm though, perfect for cold weather days and nights!
Uggs on sale------MBT shoes
MBT Fanaka GTX
MBT Fumba
MBT Tunisha
MBT Voi
MBT Boost
MBT Kaya
MBT Sapatu
MBT Fora
cheap MBT Fora

Post new comment

The content of this field is kept private and will not be shown publicly.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.

More information about formatting options

CAPTCHA
Please type in these five (5) letters or numbers to verify you aren't a SPAM Bot!
Image CAPTCHA
Copy the characters (respecting upper/lower case) from the image.