Reversal of multidrug resistance by curcumin in multiple myeloma
curcumin supplementation reverses multidrug resistance
Author: Zuo X Zhang K Xiao Q Xiao H Shrestha UK.
Publication Date: . 2009 Sep 15
Source: 1: Ann Hematol.
Source Type: online publication
In conclusion, curcumin reversed multidrug resistance of MOLP-2/R through inhibition of FA/BRCA pathway.
Most patients with multiple myeloma (MM) will relapse eventually due to the acquired multidrug resistance (MDR). The objective of this study was to explore the reversal effect of curcumin on the MDR of human MM cell line, MOLP-2/R, and analyze the role of Fanconi anemia (FA)/BRCA pathway in this process. MOLP-2/R was selected by stepwise exposure of parental MOLP-2 cells to increasing concentrations of melphalan. The MTT assay was used to detect the reversal ratio of curcumin. The FANCD2 monoubiquitination expression was detected by western blotting to explore the role of FA/BRCA pathway. Cell cycle, apoptosis, and intracellular drug concentration were analyzed by flow cytometry. The results indicated that combination of melphalan with curcumin had stronger effects on the proliferation inhibition, inducement of apoptosis, G2/M phase arrest, and enhancement of intracellular drug concentration than melphalan alone in MOLP-2/R cells. These effects were accompanied with inhibition of FA/BRCA pathway by down regulation of FANCD2 protein monoubiquitination in a dose-dependent manner. In conclusion, curcumin reversed multidrug resistance of MOLP-2/R through inhibition of FA/BRCA pathway. The possible mechanisms include (1) reduction of DNA damage repair and stimulation of apoptosis of tumor cells through inhibition of FA/BRCA pathway, which is important for DNA repair, and (2) achievement of high concentration in target cells. Curcumin may be a safe reversal agent of multidrug resistance with low-dose DNA cross-linking agents.






do they work with valcade, ?
does liopic acid work for nerve damage in multiple myeloma
Anonymous-
I can't tell from your question exactly what you are asking.
Does ALA and curcumin "work with velcade" meaning does curcumin eliminate the body's resistance to velcade? The article above does not specify which chemos so I would ask your onc this question.
As for the second question, does ALA work for nerve damage? All I can say is that ALA is one the list of supplements common to lists from places like Dana-Farber to manage peripheral neuropathy so from this perspective, I would say that ALA works for nerve damage.
David Emerson
ALA worked EXCELLENT for us. Dave took 800 mg 2 daily and up to 2400 mg daily if needed. We were only asked not to take it during the 4 days of high dose chemotherapy when getting a consolidation or stem cell transplant. We honored that, and took the neurontin if needed and then switched back to the ALA. You should include B6, B 12 shots if you can get them from your doctor, and folic acid. PN in healthy people is caused by a Vitamin B deficiency. Hope that helps.
Lori
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