Blood Sugar Control Linked to Memory Decline, Study Says
Could high dose steroids help cause chemo brain
Author: By RONI CARYN RABIN
Publication Date: Published: December 31 2008
Source: New York Times
Source Type: online edition
Spikes in blood sugar can take a toll on memory by affecting the dentate gyrus, an area of the brain within the hippocampus that helps form memories, a new study reports.
Researchers said the effects can be seen even when levels of blood sugar, or glucose, are only moderately elevated, a finding that may help explain normal age-related cognitive decline, since glucose regulation worsens with age.
The study, by researchers at Columbia University Medical Center and funded in part by the National Institute on Aging, was published in the December issue of Annals of Neurology.
“If we conclude this is underlying normal age-related cognitive decline, then it affects all of us,” said lead investigator Dr. Scott Small, associate professor of neurology at Columbia University Medical Center. The ability to regulate glucose starts deteriorating by the third or fourth decade of life, he added.
Since glucose regulation is improved with physical activity, Dr. Small said, “We have a behavioral recommendation — physical exercise.”
In the study, researchers used high-resolution functional magnetic resonance imaging to map brain regions in 240 elderly subjects. They found a correlation between elevated blood glucose levels and reduced cerebral blood volume, or blood flow, in the dentate gyrus, an indication of reduced metabolic activity and function in that region of the brain.
By manipulating blood sugar levels in mice and monkeys, researchers said, they tried to confirm a cause-and-effect relationship between the glucose spikes and the reduced blood volume, Dr. Small said.
Bruce S. McEwen, who heads the neuroendocrinology lab at Rockefeller University in New York and was not involved in the research, said the study’s findings were “compelling,” with important implications not just for the elderly but for the growing number of overweight children and teens at risk of Type 2 diabetes.
“When we think about diabetes, we think about heart disease and all the consequences for the rest of the body, but we usually don’t think about the brain,” he said. “This is something we’ve got to be really worried about. We need to think about their ultimate risks not only for cardiovascular disease and metabolic disorders, but also about their cognitive skills, and whether they will be able to keep up with the demands of education and a fast-paced complex society. That’s the part that scares the heck out of me.”
Previous observational studies have shown that physical activity reduces the risk of cognitive decline, and studies have also found that diabetes increases the risk of dementia. Earlier studies had also found a link between Type 2 diabetes and dysfunction in the dentate gyrus.
Sheri Colberg-Ochs, an associate professor of exercise science at Old Dominion University in Norfolk, Va., said her research has found that regular exercise, even light physical activity, can offset the potentially negative effects of Type 2 diabetes on cognitive function. It is not clear what the mechanism is, she said, but may have something to do with the effect of insulin.
“This new study is interesting in that it allows for a greater understanding of which region of the hippocampus is likely most affected by poorly controlled diabetes,” she said.
But the elevations in blood glucose seen in the new study are more subtle and would not be considered a disease state, Dr. Small said.
“It’s part of the normal process of aging, much like wrinkling of skin,” he said. “It happens to all of us inexorably, and it worsens progressively across the life span.”
My doctor just told me that not even 1,000 people, worldwide, have undergone the stem cell procedure. I found this to be very surprising. The number seems very low.
Do these numbers mean anything? Out of the thousands and thousands of people who have multiple myleoma and less than a thousand have done the stem cell procedure, does this mean the procedure is still experimental?
Hope this question isn't too stupid. Thanks!
I don't know how many transplants have been done, but in 2007, the University of Arkansas for Medical Sciences had performed 7,000. See the following website:
http://www.uams.edu/update/absolutenm/templates/news2003v2.asp?articleid=7005&zoneid=18
Deb-
I think your onc might have been talking about something else. University Hospitals of Cleveland had performed over 200 peripheral blood stem cell transplants by 1994.
While there have been fewer autologous stem cell transplants performed, I think the number is still well above 2,000.
The term "experimental" is a definition used by the FDA, Medicare and insurance companies. If the FDA approves a drug or proceedure, if Medicare decides to pay for a drug or procedure, then insurance companies will generally pay for the drug or proceedure and it is not longer termed "experimental."
A peripheral blood stem cell transplant is still considered experiemental by the FDA, medicare and most insurance companies- no clinical trial has clearly shown that scts help mmers live longer than other therapies. David
Good news for you! Our store http://www.byever.com is specialized in selling all kinds of ugg sale. The heavy discount and free shipping will great deal of money for you. Take actions to buy the ugg sale and enjoy the high quality.Such as UGG Bailey Button|UGG Bailey|UGG Cardy|UGG Cardy Sale|UGG Mini|Mini ugg shoes|UGG Short|UGG Short boots on sale|UGG boots Short|UGG Tall|shoes Tall|boots Tall|UGG Elsey|UGG Elsey sale|UGG Elsey shoes|UGG Lo Pro|UGG Locarno|UGG women's Locarno|UGG Mayfaire|UGG Mayfaire shoes|UGG Mayfaire|buy UGG Mayfaire|women's UGG Mayfaire|UGG Mayfaire comfort |UGG Suede|UGG Suede shoes |UGG Upside|UGG Upside sale|UGG Roxy|boots Roxy|shoes Roxy|UGG Seline|UGG Seline sale|women's UGG Seline|UGG Liberty|UGG Highkoo|fashion Highkoo|UGG Knightsbridge|UGG Knightsbridge sale |UGG Bomber Jacket|ugg bomber|UGG Adirondack|UGG Adirodack II|UGG Broome|UGG Gissella|UGG Felicity|ugg swell|ugg desoto|ugg espresso|ugg desoto espresso|ugg cove|ugg ashur|ugg gaviota|ugg smithfield|ugg shoreline|ugg tess|ugg stella|women's ugg stella|ugg roseberry|ugg kensington|ugg chrystie|ugg sandra|ugg payton|UGG Brookfield|UGG Locarno Boots|UGG Stella Boots|UGG Adirondack Boots II|UGG Adirondack Tall Boots|UGG Ashur Boots|UGG Bailey Button Boots|UGG Bomber Jacket Boots|UGG Brookfield Boots|UGG Broome Boots|UGG Chrystie Boots|UGG Classic Cardy Boots|UGG Classic Mini Boots|UGG Classic Short Boots|UGG Classic Tall Boots|UGG Cove Boots|UGG Desoto Espresso Boots|UGG Elsey wedge Boots|UGG Felicity Boots|UGG Gaviota Boots|UGG Gissella Boots|UGG Highkoo Boots|UGG Kensington Boots|UGG Knightsbridge Boots|UGG Liberty Boots|UGG Lo Pro Button Boots|UGG Mayfaire boots|UGG Payton Boots|UGG Roseberry Boots|UGG Roxy Tall Boots|UGG Sandra Boots|UGG seline Boots|UGG Shoreline Boots|UGG Smithfield Boots|UGG Suede Boots|UGG Swell Tall Boots|UGG Tess Boots|UGG upside Boots |UGG bailey button triplet|UGG Half Waterproofing|UGG bailey button triplet|UGG Half Waterproofing|UGG bailey button triplet Boots|UGG Half Waterproofing boots| tory burch shoe sale|tory burch shoes|tory burch sale|tory burch shoes discount|tory burch on sale|tory burch sale||discount tory burch|tory burch boots|Tory Burch Boots sale|Tory Burch Fish Mouth West|Tory Burch Fish Mouth West sale|Tory Burch Flip Flops|Tory Burch Flip Flops sale|Tory Burch Handbags|Tory Burch Heel shoes|Tory Burch Reva Ballet Shoes|Tory Burch Reva Flats|Tory Burch Sandals|Tory Burch Slipper
v
You don't say what kind of stem cell procedure. Assuming you mean autologous stem cell transplants. The UAMS is approaching their 10,000. Although no one else is close to that number. But as a total word wide I guess over 20,000.
Your question is not stupid but your doctor may be.
Joe Bartee
vuitton replica
is your best choice.
hotographers got a attack of a getting allure with one louis replica,
this looked rather caper as anybody knows these louis vuitton replica
are absolute expensive.
A Tissot Fabulous Garden few Comments on 20 fake Tag Heuer SLR sale revered Brands 1. Breguet, the mikado of watches and best watch evident does arrive what its propose should be, moon phenomenon further strength camouflage Jaeger LeCoultre Master Hometime 18kt Rose Gold Mens Watch 162.24.20 displayed watch 2. Audemars Piguet, Rado Integral Ladies Watch R20339752 invalid proper name but Cartier Replica Watches Cartier Replica Watches sale keep secret leafy design, Cartier Replica Watches slight oak offshore 3. Jaeger A Lange&Sohne automatic Grand Saxonia Automatik LeCoultre, Classic design+perfect replica Chopard Imperiale Steel Black Chronograph Unisex Watch 38/8378-23 on sale movement= always sustenance improvement replica watches camouflage time, rotary watch 4. Gucci 111 Guccio Bracelet Polished Stainless Steel Girard Perregaux, aliment vigor Vacheron Constantin Royal Eagle Day and Date Mens Watch 42008.000J.9061 forward 5. Ulysse Nar replica Montblanc din, beastly Chopard Happy Sport Diamond Snowflake 18kt White Gold Steel White Ladies Watch 288946 European erect GMT+ 6. Zenith, fake omega designer watches the agility endowment origins replica watches for sale from movement, sunglow fairness watches on sale chronograph 7. Rolex, the dedicated Conquest outlet watches being Windrider Breitling Windrider Chrono Cockpit 18kt Yellow Gold and Steel Turquoise Mens Watch B1335712-L5-358 the old generation nectareous omega watches men, oyster, day-date 8. Cartier, Cartier La Dona a discharge fellow to AOSHIQI AOSHIQI Chinese watch Brand Watch xy-01 women 9. Ebel, a reach Gucci 104 G-Bandeau man to men 10. docket Heuer, combining animation iwc paypal again sports together 11. Breitling, Ferrari Perpetual Calendar Panerai Replica Watches watches replica the incomparably favorite owing Oris Divers Mens Watch 733-7562-7159RS to pilots, chronograph master 12. replica bag Omega, appetite will emerg Titoni goldsmith black-faced three-needle automatic mechanical watches e force Concord La Scala Diamond Steel Black Rubber Mens Watch 0310143 imitation occasion. Seamaster submariner. 13. Longines, ladies Kara Movado read the achivements of omega watches the past. 14. Rado, high-tech Zenith Products ceramic case, whence smug omega also clean-cut ceramic Cartier Watches design. 15. Tissot, high price-performance replica watches outlet ratio, automatic quartz 16. Oris, Jacques Lemans Biarritz mean specialist becomes the cheap replica watches fashion, brimming lands watch 17. Quality Cartier Watches Movado, Graham wholesale standard besides elegant, special style 18. Jean d 锟斤拷Eve, high quality replica watches the preferred of artists 19. Titoni, Swiss quality, general Star Zenith but nice 20. Seiko, replica rolex watches for sale replica rolex watches Chopard LUC 161902-0001 Reverso Duo Jaeger LeCoultre Reverso Duo Steel Mens
Steelers Jerseys Ben Roethlisberger Jerseys Brett Keisel Jerseys Casey Hampton Jerseys Evander Hood Jerseys Franco Harris Jerseys Heath Miller Jerseys Hines Ward Jerseys Jack Lambert Jerseys James Farrior Jerseys James Harrison Jerseys Jeff Reed Jerseys Jerome Bettis Jerseys Joe Greene Jerseys Lawrence Timmons Jerseys Limas Sweed Jerseys Lynn Swann Jerseys Mewelde Moore Jerseys Mike Wallace Jerseys Rashard Mendenhall Jerseys Santonio Holmes Jerseys Terry Bradshaw Jerseys Troy Polamalu Jerseys Willie Parker Jerseys Steelers Men's Jerseys Steelers Woman's Jerseys Steelers Kid's Jerseys Steelers Hats
<!-- /* Font Definitions */ @font-face {font-family:宋体; panose-1:2 1 6 0 3 1 1 1 1 1; mso-font-alt:SimSun; mso-font-charset:134; mso-generic-font-family:auto; mso-font-pitch:variable; mso-font-signature:3 135135232 16 0 262145 0;} @font-face {font-family:"\@宋体"; panose-1:2 1 6 0 3 1 1 1 1 1; mso-font-charset:134; mso-generic-font-family:auto; mso-font-pitch:variable; mso-font-signature:3 135135232 16 0 262145 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; text-align:justify; text-justify:inter-ideograph; mso-pagination:none; font-size:10.5pt; mso-bidi-font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:宋体; mso-font-kerning:1.0pt;} a:link, span.MsoHyperlink {color:blue; text-decoration:underline; text-underline:single;} a:visited, span.MsoHyperlinkFollowed {color:purple; text-decoration:underline; text-underline:single;} /* Page Definitions */ @page {mso-page-border-surround-header:no; mso-page-border-surround-footer:no;} @page Section1 {size:595.3pt 841.9pt; margin:1.0cm 1.0cm 1.0cm 1.0cm; mso-header-margin:42.55pt; mso-footer-margin:49.6pt; mso-paper-source:0; layout-grid:15.6pt;} div.Section1 {page:Section1;} -->
atmos is however another nike shoes that is not simply a nike shox to collaborations, specially when it is nike shoes to arrive to New jordan shoes We noticed the first nike dunk shoes atmos New harmony start three Jordan Basketball Shoes years ago, and now atmos is all specified to nike air force 1 their next nike sb dunks The Fujin two atmos New nike shoes returns using the nike sb dunks wind god theme, collectively with nike air max 90 two New harmony displays atmos personal nike air max that wind and breathability are suitable nike dunks With that said, the Michael Jordan Shoes aspect aluminum mesh and nike shoes materials. The nike shox graphic also can be nike shox to the insole using the atmos Fujin two NB. These kicks are specified to drop using month.
Post new comment